Uterus transplantation: Which indications?

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چکیده

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Transplantation of the uterus.

Most women with uterine factor infertility have today no prospect of carrying a pregnancy to term. The development of a method for transplantation of the human uterus would be a means for many of these women to become both genetic and gestational mothers. In this article we review the literature concerning the history and recent development in the area of uterine transplantation. We describe ou...

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Livebirth after uterus transplantation.

BACKGROUND Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet been reported. METHODS In 2013, a 35-year-old woman with congenital absence of the uterus (Rokitansky syndrome) un...

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Experimental uterus transplantation.

BACKGROUND Uterus transplantation (UTx) is developed in animal models as a future method to treat uterine factor infertility. METHODS All published studies in the area of UTx research were identified. Aspects relating to surgery, cold-ischemia/reperfusion, rejection, immunosuppression, pregnancy, ethics and institutional requirements were examined. RESULTS Uterus retrieval surgery has been ...

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Uterus transplantation and beyond

Uterus transplantation is today the only available treatment for absolute uterine factor infertility which is caused by either congenital/surgical uterine absence or that a present uterus is non-functioning. Structured animal-based research, from rodents to nonhuman primates, was the scientific basis for a successful introduction of uterus transplantation as a clinical procedure. The patient gr...

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Indications for cardiac transplantation.

The prognosis of patients with end stage cardiac failure is poor. It can be improved by medical treatment, for example by adding vasodilators' or angiotensin converting enzyme inhibitors2 to diuretic treatment. None the less, the survival rate at 12 months in a group treated with enalapril was only 53%.2 At Papworth Hospital the cumulative survival rate for patients treated with "triple" immuno...

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ژورنال

عنوان ژورنال: Journal of Gynecology Obstetrics and Human Reproduction

سال: 2019

ISSN: 2468-7847

DOI: 10.1016/j.jogoh.2018.10.003